Pesquisa | BVS IEC

1.

Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4⁺ T Cells in COVID-19.

Meckiff, Benjamin J; Ramírez-Suástegui, Ciro; Fajardo, Vicente; Chee, Serena J; Kusnadi, Anthony; Simon, Hayley; Eschweiler, Simon; Grifoni, Alba; Pelosi, Emanuela; Weiskopf, Daniela; Sette, Alessandro; Ay, Ferhat; Seumois, Grégory; Ottensmeier, Christian H; Vijayanand, Pandurangan.

Cell ; 183(5): 1340-1353.e16, 2020 11 25.

Artigo em Inglês | MEDLINE | ID: mdl-33096020

2.

α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming.

Liu, Pu-Ste; Wang, Haiping; Li, Xiaoyun; Chao, Tung; Teav, Tony; Christen, Stefan; Di Conza, Giusy; Cheng, Wan-Chen; Chou, Chih-Hung; Vavakova, Magdalena; Muret, Charlotte; Debackere, Koen; Mazzone, Massimiliano; Huang, Hsien-Da; Fendt, Sarah-Maria; Ivanisevic, Julijana; Ho, Ping-Chih.

Nat Immunol ; 18(9): 985-994, 2017 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-28714978

3.

The transcription factor Runx3 guards cytotoxic CD8⁺ effector T cells against deviation towards follicular helper T cell lineage.

Shan, Qiang; Zeng, Zhouhao; Xing, Shaojun; Li, Fengyin; Hartwig, Stacey M; Gullicksrud, Jodi A; Kurup, Samarchith P; Van Braeckel-Budimir, Natalija; Su, Yao; Martin, Matthew D; Varga, Steven M; Taniuchi, Ichiro; Harty, John T; Peng, Weiqun; Badovinac, Vladimir P; Xue, Hai-Hui.

Nat Immunol ; 18(8): 931-939, 2017 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-28604718

4.

Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin.

Kanayama, Masashi; Xu, Shengjie; Danzaki, Keiko; Gibson, Jason R; Inoue, Makoto; Gregory, Simon G; Shinohara, Mari L.

Nat Immunol ; 18(9): 973-984, 2017 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-28671690

5.

The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.

Gorman, Jacquelyn A; Hundhausen, Christian; Errett, John S; Stone, Amy E; Allenspach, Eric J; Ge, Yan; Arkatkar, Tanvi; Clough, Courtnee; Dai, Xuezhi; Khim, Socheath; Pestal, Kathleen; Liggitt, Denny; Cerosaletti, Karen; Stetson, Daniel B; James, Richard G; Oukka, Mohamed; Concannon, Patrick; Gale, Michael; Buckner, Jane H; Rawlings, David J.

Nat Immunol ; 18(7): 744-752, 2017 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-28553952

6.

SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-ß signaling.

Cortez, Victor S; Ulland, Tyler K; Cervantes-Barragan, Luisa; Bando, Jennifer K; Robinette, Michelle L; Wang, Qianli; White, Andrew J; Gilfillan, Susan; Cella, Marina; Colonna, Marco.

Nat Immunol ; 18(9): 995-1003, 2017 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-28759002

7.

Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1.

Johnson, Louise A; Banerji, Suneale; Lawrance, William; Gileadi, Uzi; Prota, Gennaro; Holder, Kayla A; Roshorm, Yaowaluck M; Hanke, Tomás; Cerundolo, Vincenzo; Gale, Nicholas W; Jackson, David G.

Nat Immunol ; 18(7): 762-770, 2017 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-28504698

8.

Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota.

Nagashima, Kazuki; Sawa, Shinichiro; Nitta, Takeshi; Tsutsumi, Masanori; Okamura, Tadashi; Penninger, Josef M; Nakashima, Tomoki; Takayanagi, Hiroshi.

Nat Immunol ; 18(6): 675-682, 2017 06.

Artigo em Inglês | MEDLINE | ID: mdl-28436956

9.

Translation is actively regulated during the differentiation of CD8⁺ effector T cells.

Araki, Koichi; Morita, Masahiro; Bederman, Annelise G; Konieczny, Bogumila T; Kissick, Haydn T; Sonenberg, Nahum; Ahmed, Rafi.

Nat Immunol ; 18(9): 1046-1057, 2017 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-28714979

10.

Identification of lineage-specifying cytokines that signal all CD8⁺-cytotoxic-lineage-fate 'decisions' in the thymus.

Etzensperger, Ruth; Kadakia, Tejas; Tai, Xuguang; Alag, Amala; Guinter, Terry I; Egawa, Takeshi; Erman, Batu; Singer, Alfred.

Nat Immunol ; 18(11): 1218-1227, 2017 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-28945245

11.

YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKKÉ-mediated phosphorylation.

Wang, Shuai; Xie, Feng; Chu, Feng; Zhang, Zhengkui; Yang, Bing; Dai, Tong; Gao, Liang; Wang, Lin; Ling, Li; Jia, Junling; van Dam, Hans; Jin, Jin; Zhang, Long; Zhou, Fangfang.

Nat Immunol ; 18(7): 733-743, 2017 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-28481329

12.

Single-cell analysis defines the divergence between the innate lymphoid cell lineage and lymphoid tissue-inducer cell lineage.

Ishizuka, Isabel E; Chea, Sylvestre; Gudjonson, Herman; Constantinides, Michael G; Dinner, Aaron R; Bendelac, Albert; Golub, Rachel.

Nat Immunol ; 17(3): 269-76, 2016 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-26779601

13.

CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors.

Kalekar, Lokesh A; Schmiel, Shirdi E; Nandiwada, Sarada L; Lam, Wing Y; Barsness, Laura O; Zhang, Na; Stritesky, Gretta L; Malhotra, Deepali; Pauken, Kristen E; Linehan, Jonathan L; O'Sullivan, M Gerard; Fife, Brian T; Hogquist, Kristin A; Jenkins, Marc K; Mueller, Daniel L.

Nat Immunol ; 17(3): 304-14, 2016 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-26829766

14.

Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity.

Xia, Pengyan; Ye, Buqing; Wang, Shuo; Zhu, Xiaoxiao; Du, Ying; Xiong, Zhen; Tian, Yong; Fan, Zusen.

Nat Immunol ; 17(4): 369-78, 2016 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-26829768

15.

DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis.

Starokadomskyy, Petro; Gemelli, Terry; Rios, Jonathan J; Xing, Chao; Wang, Richard C; Li, Haiying; Pokatayev, Vladislav; Dozmorov, Igor; Khan, Shaheen; Miyata, Naoteru; Fraile, Guadalupe; Raj, Prithvi; Xu, Zhe; Xu, Zigang; Ma, Lin; Lin, Zhimiao; Wang, Huijun; Yang, Yong; Ben-Amitai, Dan; Orenstein, Naama; Mussaffi, Huda; Baselga, Eulalia; Tadini, Gianluca; Grunebaum, Eyal; Sarajlija, Adrijan; Krzewski, Konrad; Wakeland, Edward K; Yan, Nan; de la Morena, Maria Teresa; Zinn, Andrew R; Burstein, Ezra.

Nat Immunol ; 17(5): 495-504, 2016 May.

Artigo em Inglês | MEDLINE | ID: mdl-27019227

16.

Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation.

Minnich, Martina; Tagoh, Hiromi; Bönelt, Peter; Axelsson, Elin; Fischer, Maria; Cebolla, Beatriz; Tarakhovsky, Alexander; Nutt, Stephen L; Jaritz, Markus; Busslinger, Meinrad.

Nat Immunol ; 17(3): 331-43, 2016 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-26779602

17.

The tumor suppressor PTEN has a critical role in antiviral innate immunity.

Li, Shun; Zhu, Mingzhu; Pan, Ruangang; Fang, Ting; Cao, Yuan-Yuan; Chen, Shuliang; Zhao, Xiaolu; Lei, Cao-Qi; Guo, Lin; Chen, Yu; Li, Chun-Mei; Jokitalo, Eija; Yin, Yuxin; Shu, Hong-Bing; Guo, Deyin.

Nat Immunol ; 17(3): 241-9, 2016 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-26692175

18.

Epigenetic regulation of the expression of Il12 and Il23 and autoimmune inflammation by the deubiquitinase Trabid.

Jin, Jin; Xie, Xiaoping; Xiao, Yichuan; Hu, Hongbo; Zou, Qiang; Cheng, Xuhong; Sun, Shao-Cong.

Nat Immunol ; 17(3): 259-68, 2016 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-26808229

19.

Classical dendritic cells are required for dietary antigen-mediated induction of peripheral T(reg) cells and tolerance.

Esterházy, Daria; Loschko, Jakob; London, Mariya; Jove, Veronica; Oliveira, Thiago Y; Mucida, Daniel.

Nat Immunol ; 17(5): 545-55, 2016 May.

Artigo em Inglês | MEDLINE | ID: mdl-27019226

20.

The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity.

Gonzalez-Martin, Alicia; Adams, Brian D; Lai, Maoyi; Shepherd, Jovan; Salvador-Bernaldez, Maria; Salvador, Jesus M; Lu, Jun; Nemazee, David; Xiao, Changchun.

Nat Immunol ; 17(4): 433-40, 2016 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-26901150

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Instituto Evandro Chagas

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